DNA DOUBLE-STRAND BREAK REPAIR FUNCTIONS DEFEND AGAINST PARVOVIRUS INFECTION

We measured parvovirus replication and sensitivity to X-ray damage in nine CHO fell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radios ensitivity. Parvovirus replication is disrupted at an early stage of i nfection in DNA repair-proficient cells, before conversion of the sing le-stranded viral DNA genome into the double-stranded replicative form . Thus, status of the DNA repair machinery inversely correlates with p arvovirus replication and is proportional to the host's ability to rep air X-ray-induced damage.