CHARACTERIZATION OF TUMOR-CELL LINES DERIVED FROM MURINE GAMMAHERPESVIRUS-68-INFECTED MICE

Authors
USHERWOOD EJ STEWART JP NASH AA
Citation
Ej. Usherwood et al., CHARACTERIZATION OF TUMOR-CELL LINES DERIVED FROM MURINE GAMMAHERPESVIRUS-68-INFECTED MICE, Journal of virology, 70(9), 1996, pp. 6516-6518
Citations number
20
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
70
Issue
9
Year of publication
1996
Pages
6516 - 6518
Database
ISI
SICI code
0022-538X(1996)70:9<6516:COTLDF>2.0.ZU;2-X
Abstract
Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV -68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and releas ed virus. The line was clonable and grew into tumors in nude mice. Thi s is the first naturally occurring MHV-68-positive B-cell line to be g enerated, and it will be an invaluable tool for the study of MHV-68 la tency.