CERBERUS IS A HEAD-INDUCING SECRETED FACTOR EXPRESSED IN THE ANTERIORENDODERM OF SPEMANNS ORGANIZER

Authors
BOUWMEESTER T KIM SH SASAI Y LU B DEROBERTIS EM
Citation
T. Bouwmeester et al., CERBERUS IS A HEAD-INDUCING SECRETED FACTOR EXPRESSED IN THE ANTERIORENDODERM OF SPEMANNS ORGANIZER, Nature, 382(6592), 1996, pp. 595-601
Citations number
48
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Nature → ACNP
ISSN journal
00280836
Volume
382
Issue
6592
Year of publication
1996
Pages
595 - 601
Database
ISI
SICI code
0028-0836(1996)382:6592<595:CIAHSF>2.0.ZU;2-H
Abstract
An abundant cDNA enriched in Spemann's organizer, cerberus, was isolat ed by differential screening. It encodes a secreted protein that is ex pressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the ant erior endoderm in the induction of head structures in the vertebrate e mbryo.