3 ALLELIC FORMS OF THE HUMAN ENDOGENOUS RETROVIRUS, ERV3, AND THEIR FREQUENCIES IN MULTIPLE-SCLEROSIS PATIENTS AND HEALTHY-INDIVIDUALS

A possible association between the endogenous retrovirus, ERV3, and mu ltiple sclerosis (MS) was exmined, Samples of DNA from 74 MS patients and 159 healthy blood donors were subjected to enzymatic amplification followed by single strand conformational analysis to detect polymorph isms in the long terminal repeats of ERV3, Using this approach we dete cted six single base pair variations and a drop-out of a nucleotide. T he linkage pattern of these base pair variations enabled us to define three allelic forms of ERV3, Polymorphisms exclusively present in the group of patients were not found and the distribution of the three all elic forms did not differ significantly between the group of controls and the MS group, Neither was there a significant difference in the di stribution of the three alleles between MS patients with the progressi ve form and patients with relapsing/remitting MS, Our results are not in support of an association between ERV3 and MS.