STABILITY AND COMPATIBILITY STUDY OF A CARBOPLATIN SOLUTION IN SYRINGES FOR CONTINUOUS AMBULATORY INFUSION

The aim of this study was to verify the physico-chemical stability and compatibility between a 10 mg/ml carboplatin parenteral solution and the portable pump Intelliject(R) when stored at 25 degrees C over an 8 -day period. During this study, the pH was determined and carboplatin degradation products were assayed by a validated HPLC method. The comp atibility study consisted of the titration of reducing substances, TLC of extracted additives, assay of extracted ions by AAS, resistivity m easure, dynamometric test and UV, visible and IR absorption spectropho tometry. Stability and compatibility studies showed that a 10 mg/ml ca rboplatin parenteral solution remained chemically stable in the Intell iject(R) pump over a period of 8 days under the tested conditions.