TRANSFORMING GROWTH-FACTOR-ALPHA OVEREXPRESSION IN PROLIFERATIVE VERRUCOUS LEUKOPLAKIA AND ORAL SQUAMOUS-CELL CARCINOMA - AN IMMUNOHISTOCHEMICAL STUDY

Citation
R. Kannan et al., TRANSFORMING GROWTH-FACTOR-ALPHA OVEREXPRESSION IN PROLIFERATIVE VERRUCOUS LEUKOPLAKIA AND ORAL SQUAMOUS-CELL CARCINOMA - AN IMMUNOHISTOCHEMICAL STUDY, Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 82(1), 1996, pp. 69-74
Citations number
42
Categorie Soggetti
Pathology,Surgery,"Dentistry,Oral Surgery & Medicine
ISSN journal
10792104
Volume
82
Issue
1
Year of publication
1996
Pages
69 - 74
Database
ISI
SICI code
1079-2104(1996)82:1<69:TGOIPV>2.0.ZU;2-L
Abstract
Proliferative verrucous leukoplakia is a unique type of oral leukoplak ia that has a high risk of malignant transformation. The aim of this s tudy was to examine the expression of transforming growth factor-alpha in proliferative verrucous leukoplakia, oral squamous cell carcinoma, and normal mucosa. Transforming growth factor-alpha, a potent mitogen , is known to play an important role in various neoplasms including or al squamous cell carcinoma. Immunohistochemical localization of transf orming growth factor-alpha in archival paraffin-embedded sections was performed with commercially available monoclonal antibodies. Ten cases each ai normal mucosa, proliferative verrucous leukoplakia, and oral squamous cell carcinoma were stained. Quantification oi the staining i ntensity, expressed as the cytoplasmic optical density, was done with the Roche Image Analysis System. The data were statistically analyzed with the one-way analysis of variance and Tukey tests. Notably, the me an cytoplasmic optical density of proliferative verrucous leukoplakia was significantly higher than the mean cytoplasmic optical density of normal mucosa (p < 0.01). squamous cell carcinoma, however, this diffe rence was not significant (p > 0.05). The mean cytoplasmic optical den sity values demonstrate that increased transforming growth factor-alph a immunoreactivity occurs in proliferative verrucous leukoplakia and o ral squamous cell carcinoma relative to normal mucosa.