EFFICACY OF TENOXICAM ON INTRAABDOMINAL ADHESION PREVENTION IN A RAT MODEL

The aim of this study was to investigate the effect of tenoxicam as a non-steroidal anti-inflammatory drug (NSAID) on intra-abdominal adhesi on prevention in a rat model. Altogether 50 Wistar-Albino rats weighin g 220 - 280 g were assigned to five groups, each of which was made up of 10 rats. All the rats were anaesthetized and prepared for sterile s urgery. After a mid-line laparotomy was performed, a 1 cm area of the caecum was rubbed with gauze until subserosal haemorrhage developed, a nd then a 5 mm-diameter part of the peritoneum on the right side of th e abdominal wall was removed. Prior to complete closure, 3 ml of the t est material was placed into the abdominal cavity. On the eighth day t he rats were killed and the adhesion score was determined. The groups and their mean adhesion scores were as follows: control group (normal saline), 2.5; group of dilution buffer, 1.8; tenoxicam (0.125 mg/kg), 1.3; tenoxicam (0.25 mg/kg), 1.3; and tenoxicam (0.5 mg/kg), 0.9. The differences between the adhesion scores among all the groups (P < 0.05 , Kruskal-Wallis test), and those between the tenoxicam groups and con trol group (P < 0.05, Mann-Whitney U-test), were significant. Thus a s ingle instillation of tenoxicam into the peritoneal cavity at the time of surgery reduced adhesion formation effectively in this model, irre spective of dosage.