INHIBITORY EFFECTS OF INDOMETHACIN ON IMPLANTATION AND ITS RELATED PHENOMENA

The dose-response relationship for the inhibitory effect of indomethac in on implantation and continuance of pregnancy was examined in four g roups of rabbits administered with indomethacin (2.5, 5.0, 7.5 and 10. 0 mg/kg) during the implantation period and compared with a control gr oup. Implanted fetuses and corpora lutea were counted by laparotomy, a nd the number of offspring born was noted, The inhibitory effect of in domethacin on implantation was found to be dose-dependent, and the bir th rate decreased in the indomethacin groups compared with the control group. As a result, even where implantation had been achieved, death of the implanted fetuses occurred at a high rate in rabbits administer ed with indomethacin during the implantation period.