V. Volf et al., TREATMENT WITH 3,4,3-LIHOPO OF SIMULATED WOUNDS CONTAMINATED WITH PLUTONIUM AND AMERICIUM IN RAT, International journal of radiation biology, 70(1), 1996, pp. 109-114
The effect of a siderophore analogue 3,4,3-LIHOPO has been investigate
d in rat after intramuscular injection of Pu-238, Pu-239 and Am-241 si
mulating puncture wounds. Various treatment regimens were used to remo
ve the radioactivity from its injection site and to reduce its retenti
on in body tissues. The local deposits could be reduced to 9% of that
in untreated controls by a single local injection of 30 mu mol kg(-1)
3,4,3-LIHOPO administered 1 day after the actinides. Tissue retention
of radioactivity was most effectively reduced (to 3% of controls) by c
ontinuous subcutaneous infusion of 3,4,3-LIHOPO (3 mu mol kg(-1) day(-
1)), starting immediately after the injection of actinides and continu
ing for 2 weeks. The administration of 3,4,3-LIHOPO in drinking water
was least effective. Treatment efficacy was substantially higher with
Pu-238 than with an equal activity of Pu-239 (the Pu-239 mass, however
, was almost 300 times lower than that of Pu-239). Accordingly, the bi
okinetics and removal of Am-241 changed when it was injected with Pu-2
39 instead of Pu-238. Continuous infusion of 3,4,3-LIHOPO (3 mu mol kg
(-1) day(-1)), starting 4 and 30 days after intramuscular injection of
Pu-238 and Am-241 reduced their femoral retention after 1 month to 20
and 60% of controls respectively; whole-body retention of Am-241 was
reduced to 20 and 70% of controls respectively.