CLINICAL AND PATHOLOGICAL FINDINGS OF A YORKSHIRE TERRIER AFFECTED WITH NECROTIZING ENCEPHALITIS

A three-year-old, male Yorkshire terrier was presented with blindness, circling, hind limb weakness, and convulsive seizure for the past 3 m onths. Characteristic clinical findings were chronic, progressive neur ological signs involving cerebrum and brain stem, an elevation of brai n-type isoenzyme of serum creatine kinase, appearance of high voltage slow activity in electroencephalogram, and multifocal lesions in the c erebral hemispheres on magnetic resonance imaging. Necrotizing encepha litis of Yorkshire terrier was diagnosed after postmortem pathological examination. This is the first case report of the disease in Japan.