A. Toren et al., ORAL TUBERCULOSIS FOLLOWING AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR HODGKINS-DISEASE WITH INTERLEUKIN-2 AND ALPHA-INTERFERON IMMUNOTHERAPY, Bone marrow transplantation, 18(1), 1996, pp. 209-210
A patient with Hodgkin's disease (HD) underwent autologous bone marrow
transplantation (ABMT). Six months later while receiving interleukin
(IL)-2 and alpha-interferon immunotherapy, he developed a painful lesi
on in his oral cavity with a fistula in the buccal area, Excision biop
sy disclosed necrotizing granulomatous inflammation with acid-fast bac
illus. The patient received a 9-month course of isoniazide, rifampin a
nd pyranizamide, and recovered, The possible pathophysiological mechan
ism is discussed.