C. Moraferrer et C. Neumeyer, REDUCTION OF RED-GREEN DISCRIMINATION BY DOPAMINE D1 RECEPTOR ANTAGONISTS AND RETINAL DOPAMINE DEPLETION, Vision research, 36(24), 1996, pp. 4035-4044
Reduction of wavelength discrimination ability in the 560-640 nm range
, but not in the 404-540 nm range, has been demonstrated in goldfish a
fter intravitreal injection of D1-dopamine receptor antagonists. Intra
vitreal injection of the dopaminergic neurotoxin 6-OH-dopamine severel
y reduced wavelength discrimination ability in the 540-661 nm range wi
thin 3 days. Discrimination ability could be reconstituted by the D1-a
gonist SKF 38393. Animals recovered from injection of 6-OH-dopamine wi
thin 14-16 days. No change of wavelength discrimination was induced by
6-OH-dopamine in the 461-540 nm range. We conclude that under photopi
c conditions dopamine modulates retinal mechanisms involved in red-gre
en colour coding via D1-dopamine receptor-like binding sites. Copyrigh
t (C) 1996 Elsevier Science Ltd.