DEVELOPMENT OF HYPERTHERMIA AND HYPERALGESIA FOLLOWING INTRACEREBROVENTRICULAR ADMINISTRATION OF ENDOTOXIN IN THE RAT - EFFECT OF KININ B-1AND B-2 RECEPTOR ANTAGONISTS

The present study investigated the development of hyperthermia and the rmal and mechanical hyperalgesia following i.c.v. injections of E. col i lipopolysaccharide (LPS) in rats. LPS increased core temperature and this was prevented by i.c.v. administration of HOE 140, a kinin B-2 r eceptor antagonist or by indomethacin i.c.v, or i.v. B-1 receptor anta gonists had no effect. LPS induced thermal and mechanical hyperalgesia which was reversed by i.c.v. HOE 140 and indomethacin i.c.v. and i.v. , but nor by B-1 receptor antagonists. These results indicate that inj ections of endotoxin to the CNS induces hyperthermia and hyperalgesia and that kinins, acting on centrally located B-2 receptors, and prosta noids are involved.