SIGNIFICANCE OF LYMPHOCYTIC SISTER-CHROMATID EXCHANGE FREQUENCIES IN OVARIAN-CANCER PATIENTS

Authors
DHAR PK DEVI S RAO TR KUMARI U JOSEPH A KUMAR MR NAYAK S SHREEMATI Y BHAT SM BHAT KR
Citation
Pk. Dhar et al., SIGNIFICANCE OF LYMPHOCYTIC SISTER-CHROMATID EXCHANGE FREQUENCIES IN OVARIAN-CANCER PATIENTS, Cancer genetics and cytogenetics, 89(2), 1996, pp. 105-108
Citations number
13
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
89
Issue
2
Year of publication
1996
Pages
105 - 108
Database
ISI
SICI code
0165-4608(1996)89:2<105:SOLSEF>2.0.ZU;2-P
Abstract
Very few studies report the analysis of sister chromatid exchanges in ovarian cancer patients. We tested the null hypothesis that SCE freque ncy increases with the advancing stages of ovarian cancer and follows a Poisson distribution. As controls we examined age- and sex-matched h ealthy volunteers who had no such past history. An increased overage S CE frequency was observed in ovarian cancer patients (6.34 +/- 0.09) v is-a-vis controls (4.47 +/- 0.12). Further, the data also suggested a stage-wise increase in the SCE frequency.