IDER(9)(Q10)T(9-22)(Q34-Q11) IS A RECURRENT CHROMOSOMAL ABNORMALITY IN ACUTE LYMPHOBLASTIC-LEUKEMIA AND LYMPHATIC BLASTIC PHASE OF CHRONIC MYELOGENOUS LEUKEMIA

Authors
DIERLAMM J MICHAUX L KROGER N WLODARSKA I MARTIAT P ZELLER W SEEGER D MECUCCI C VANDENBERGHE H HOSSFELD DK
Citation
J. Dierlamm et al., IDER(9)(Q10)T(9-22)(Q34-Q11) IS A RECURRENT CHROMOSOMAL ABNORMALITY IN ACUTE LYMPHOBLASTIC-LEUKEMIA AND LYMPHATIC BLASTIC PHASE OF CHRONIC MYELOGENOUS LEUKEMIA, Cancer genetics and cytogenetics, 89(2), 1996, pp. 109-113
Citations number
25
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
89
Issue
2
Year of publication
1996
Pages
109 - 113
Database
ISI
SICI code
0165-4608(1996)89:2<109:IIARCA>2.0.ZU;2-6
Abstract
We report on two cases, one with acute lymphoblastic leukemia and a se cond with lymphatic blastic phase of Philadelphia chromosome-positive chronic myelogenous leukemia, cytogenetically characterized by ider(9) (q10)t(9;22)(q34;q11). Our findings and the data of the 4 cases previo usly published indicate that ider(9)(q10)t(9;22)(q34;q11) represents a rare but recurrent chromosomal abnormality occurring in hematological malignancies with lymph old differentiation, namely acute lymphoblast ic leukemia and lymphatic blastic phase of chronic myelogenous leukemi a, and most likely evolves from a preexistent der(9) involved in the s tandard t(9;22).