Nb. Atkin et Z. Jackson, EVIDENCE FOR SOMATIC PAIRING OF CHROMOSOME-7 AND CHROMOSOME-10 HOMOLOGS IN A FOLLICULAR LYMPHOMA, Cancer genetics and cytogenetics, 89(2), 1996, pp. 129-131
Fluorescence in situ hybridization using centromeric probes for chromo
somes 7 and 10 in a follicular lymphoma revealed only one signal in ab
out 40% of interphases, whereas two copies of each chromosome were con
sistently seen in metaphases. In four out of 18 metaphases both copies
of chromosome 7 were situated close to one another. In contrast, two
signals for chromosome 1 were seen in 94% of interphases, consistent w
ith observations on metaphases. The findings suggest chromosome-specif
ic somatic pairing, the functional significance of which is at present
unknown, and reinforce previous evidence suggesting that care should
be taken in the interpretation if interphase signal numbers using cent
romeric probes in neoplastic as well as normal material.