A CASE OF ISODICENTRIC 7P AS SOLE ABNORMALITY IN A PATIENT WITH ACUTEMYELOID-LEUKEMIA

The detection of isochromosomes in the leukemias and in solid tumors h as been well described in the literature, the most common being the i( 17q), which is found in the blast crisis of CML and terminal stages of acute myeloid leukemia. Reports of isochromosome 7 have, how ever, be en less well represented, particularly isochromosomes of the short arm of chromosome 7, which represent approximately 1% of all reported iso chromosomes in neoplasia. We present here a case report of an elderly female patient with AML-M2 who manifested an idic(7p) in the majority of her bone marrow cells. Fluorescence in situ hybridization (FISH) st udies with bath centromere-7-and chromosome-7-specific DNA probes veri fied the diagnosis of idic(7p). To the best of our knowledge, this is the first report of this type of leukemia with an acquired idic(7p) as the sole cytogenetic abnormality.