FAMILIAL SUPERNUMERARY CHROMOSOME AND MALIGNANCY

Authors
MILUNSKY JM WYANDT HE MILUNSKY A
Citation
Jm. Milunsky et al., FAMILIAL SUPERNUMERARY CHROMOSOME AND MALIGNANCY, Cancer genetics and cytogenetics, 89(2), 1996, pp. 170-172
Citations number
12
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
89
Issue
2
Year of publication
1996
Pages
170 - 172
Database
ISI
SICI code
0165-4608(1996)89:2<170:FSCAM>2.0.ZU;2-6
Abstract
No familial marker chromosome associated with a malignancy has been re ported to date. We used fluorescence in situ hybridization (FISH) to c haracterize a supernumerary marker chromosome 15 ascertained during pr enatal diagnosis. This supernumerary chromosome 15 was found to span t hree generations of a family. Three family members carrying the supern umerary chromosome 15 have also had malignancies, namely, a cystic gli oma, leukemia, and thyroid cancer.