Blood samples from members of the Oromo and Amhara ethnic groups of ce
ntral Ethiopia were tested for 10 erythrocyte protein systems: ACP1, A
DA, AK1, CA2, ESD, G6PD, GLO1, HB beta, PGD, and PGM1. Differences bet
ween the two samples were relatively slight and not statistically sign
ificant. Gene frequency distributions were then analyzed in the contex
t of the genetics of the African and Arabian peoples. Considering the
erythrocyte enzyme data, the Oromo and Amhara appear quite similar to
Europoids (particularly to the South Arabians) and considerably differ
ent from the Negritic peoples. There is evidence for close genetic aff
inity among the Cushitic- and Semitic-speaking population groups of th
e Kern. Admixture between Europoid and Negritic populations seems to h
ave been the main microevolutionary factor in generating the present d
ay Cushitic (and Semitic)-speaking group of eastern Africa. The result
s are consistent with the hypothesis, supported by historical and ling
uistic evidence, for a common origin of these groups from a Cushitic-s
peaking group living in eastern Africa. (C) 1996 Wiley-Liss, Inc.