S. Barbaux et al., THE XENOPUS-LAEVIS HOMOLOG OF THE 64-KDA SUBUNIT OF CLEAVAGE STIMULATION FACTOR, Comparative biochemistry and physiology. B. Comparative biochemistry, 114(3), 1996, pp. 313-315
Cleavage stimulation factor (CstF) is composed of three subunits of 50
, 64 and 77 kDa, respectively. We report here the identification of a
cDNA clone from Xenopus laevis encoding a homologue of the 64-kDa subu
nit of human CstF. Comparative sequence analysis reveals that these tw
o proteins are highly conserved with the exception of a unique repeat
structure found in the human, but not in the X. laevis, protein. Analy
sis of expression of this mRNA during X. laevis tadpole development in
dicates a requirement for this protein throughout all stages of develo
pment.