DISTRIBUTION OF 5-HT4 RECEPTOR MESSENGER-RNA IN THE RAT-BRAIN

Authors
ULLMER C ENGELS P ABDELAL S LUBBERT H
Citation
C. Ullmer et al., DISTRIBUTION OF 5-HT4 RECEPTOR MESSENGER-RNA IN THE RAT-BRAIN, Naunyn-Schmiedeberg's archives of pharmacology, 354(2), 1996, pp. 210-212
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Naunyn-Schmiedeberg's archives of pharmacology → ACNP
ISSN journal
00281298
Volume
354
Issue
2
Year of publication
1996
Pages
210 - 212
Database
ISI
SICI code
0028-1298(1996)354:2<210:DO5RMI>2.0.ZU;2-P
Abstract
We have analyzed the brain distribution of the rat 5-HT4 receptor mRNA . A receptor specific probe was used for in situ hybridization of rat brain sections. Abundant expression of the 5-HT4 receptor mRNA was obs erved in the olfactory system, striatum, medial habenula and the hippo campal formation, while faint or no specific signals could be detected in most other areas of the brain. Several brain areas which display s trong ligand binding do not contain mRNA, suggesting an axonal localiz ation of the 5-HT4 receptor.