F. Tremblay et al., VISUAL-EVOKED POTENTIALS WITH CROSSED ASYMMETRY IN INCOMPLETE CONGENITAL STATIONARY NIGHT BLINDNESS, Investigative ophthalmology & visual science, 37(9), 1996, pp. 1783-1792
Purpose. To investigate a proposed postretinal defect in patients with
the incomplete form of congenital stationary night blindness (CSNB2)
and to compare visual evoked potential (VEP) results with those found
in various forms of albinism. Methods. Visual evoked potentials were p
erformed in 10 patients with a diagnosis of CSNB2, 10 subjects with al
binism, and 17 normal subjects. Visual evoked potentials were elicited
monocularly with diffuse flash stimulation. Scalp electrodes were pla
ced over each hemisphere and referred to the forehead. Interhemispheri
c bipolar recordings were derived, and the correlation coefficient (CC
) was calculated for various segments of the interhemispheric response
s. Results, A crossed visual evoked potential asymmetry pattern could
be demonstrated in 9 of 10 patients with CSNB2. All subjects with albi
nism and none of the normal subjects showed the crossed asymmetry patt
ern. Statistical comparison of the CC computed for various segments of
the interhemispheric response shows that the pattern of inversion in
CSNB2 is more prominent in the 25 to 100 msec range (median CC, -0.37)
and in the 175 to 250 msec range (CC, -0.27). In subjects with albini
sm, all segments show a negative CC (range, -0.46 to -0.60). In normal
subjects, all segments are positively correlated (range, 0.36 to 0.66
). Conclusions. Crossed visual evoked potential asymmetry was found in
patients with CSNB2; therefore, excessive decussation, as demonstrate
d by this testing procedure, should not be considered as pathognomonic
for albinism.