DIFFERENT ADHESION TYPES AND ACTIVE SENSITIVITY OF PLATELET SUBPOPULATIONS

Two different adhesion patterns of blood platelets with different sens itivity to adenosine were demonstrated by means of reflection contrast microscopy with consecutive image analysis and cell affinity chromato graphy, High-performance liquid chromatography revealed that thrombin- induced serotonin release of adenosine-sensitive platelets was lower t han that of adenosine-resistant cells. Our results indicate platelet h eterogeneity and suggest that the platelets with lower adenosine sensi tivity may be actively involved in the early interaction between plate lets and injured endothelium. (C) 1996 Wiley-Liss, Inc.