PREPARATION OF 1-AMINOALKYLPHOSPHONIC ACIDS AND 2-AMINOALKYLPHOSPHONIC ACIDS BY REDUCTIVE AMINATION OF OXOALKYLPHOSPHONATES

By reacting dialkyl 1-oxo or 2-oxoalkylphosphonates with benzhydrylami ne followed by reduction with triacetoxyborohydride and acid hydrolysi s gave corresponding aminoalkylphosphonic acids with satisfactory yiel ds. The use of benzylamine, alpha-methylbenzylamine and tritylamine wa s unsuccessful in the case of dialkyl 1-oxoalkylphosphonates whereas c onversion of 2-oxoalkylphosphonates was also achieved although with lo wer yields. Copyright (C) 1996 Elsevier Science Ltd