Objective: To compare the lateral transabdominal and posterior retrope
ritoneal laparoscopic methods for performing adrenalectomy. Design: No
nrandomized. Setting: Hospitals affiliated with the University of Cali
fornia, San Francisco. Patients: Thirty-six patients (15 men and 21 wo
men), aged 5 to 78 years (mean age, 49 years), were treated for the fo
llowing conditions: aldosteronoma, 18 patients; pheochromocytoma, 4 pa
tients; Gushing syndrome, 6 patients; androgen-secreting tumor, 1 pati
ent; nonfunctioning adenoma, 3 patients; adrenal hemorrhage, 1 patient
; metastatic neoplasm, 2 patients; and myelolipoma, 1 patient. Interve
ntions: Twenty-three lateral and 14 posterior laparoscopic adrenalecto
mies. Main Outcome Measures: Success rate, operating time, complicatio
ns, and length of hospital stay. Results: The tumors, which ranged in
size from 1 to 13 cm (mean, 4.2 cm; median, 2.5 cm), were all successf
ully resected laparoscopically. All 8 tumors larger than 6 cm were res
ected by the lateral approach. One critically ill patient died. No pat
ient required blood transfusions or conversion to laparotomy. Mean ope
rating time was 3.8 hours vs 3.4 hours (median, 3.5 hours vs 3 hours)
and mean hospital stay was 2.2 days vs 1.5 days (median, 2 days vs 1 d
ay) for the lateral and posterior approaches, respectively. AII patien
ts without concomitant procedures were ready to be discharged within 4
8 hours. Conclusions: Both approaches were effective and safe. We pref
er the lateral approach for tumors larger than 6 cm and tile posterior
approach for bilateral tumors.