ARTERIOVENOUS-FISTULA OBSTRUCTION AND EXPRESSION OF PLATELET RECEPTORS FOR VON-WILLEBRAND-FACTOR AND FOR FIBRINOGEN (GLYCOPROTEINS GPIB ANDGPIIB IIIA) IN HEMODIALYSIS-PATIENTS/

Platelet surface receptors for von Willebrand factor and for fibrinoge n (glycoproteins GPIb and GPIIb/IIIa) were studied with monoclonal ant ibodies CD42 and CD41 and cytofluorometry in 31 healthy subjects, 10 h emodialysis patients with no A-V fistula obstruction (patent original fistula), 10 hemodialysis patients with frequent A-V fistula obstructi on (more than twice), 12 patients with mild chronic renal failure (cre atinine 1.75+/-0.40 mg/100ml), 11 patients with advanced chronic renal failure (creatinine 5.62+/-1.22 mg/100ml), and 10 patients with end-s tage renal disease (ESRD) treated with peritoneal dialysis. There was a significant increase of platelet surface glycoproteins GPIb and GPII b/IIIa in the population of hemodialysis patients with frequent A-V fi stula obstruction. The expression of these platelet receptors might be related to the prothrombotic tendency of a group of patients with ESR D, who suffer more occlusive and thrombotic events of the A-V fistula. This group of patients may also have a higher frequency of systemic t hrombotic and atherosclerotic complications.