A. Krempler et B. Brenig, MUSCLE-SPECIFIC GENE-EXPRESSION DURING EM BRYONIC-DEVELOPMENT, DTW. Deutsche tierarztliche Wochenschrift, 103(10), 1996, pp. 408-413
The myogenic bHLH-proteins play a crucial role in the determination an
d tissue specific gene expression in skeletal muscle. Being able to re
gulate themselves and the other members of their family they establish
the myogenic lineage in the precursor cells of the skeletal muscle. T
he precise mechanisms that lead to the manifestation of myogenic cells
in vivo are still unknown, but much has been learned from the behavio
ur of established cell lines and targeted mutations in the myogenic re
gulatory factors (MRFs). This review will focus on the results of thes
e experiments and outline the major regulatory pathways which lead to
the formation of skeletal muscle cells.