RING-OPENING AND RING-CLOSURE REACTIONS OF 1,2,4-TRIAZINES WITH CARBON NUCLEOPHILES - A NOVEL ROUTE TO FUNCTIONALIZED 3-AMINOPYRIDAZINES

Authors
RYKOWSKI A WOLINSKA E
Citation
A. Rykowski et E. Wolinska, RING-OPENING AND RING-CLOSURE REACTIONS OF 1,2,4-TRIAZINES WITH CARBON NUCLEOPHILES - A NOVEL ROUTE TO FUNCTIONALIZED 3-AMINOPYRIDAZINES, Tetrahedron letters, 37(32), 1996, pp. 5795-5796
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
32
Year of publication
1996
Pages
5795 - 5796
Database
ISI
SICI code
0040-4039(1996)37:32<5795:RARRO1>2.0.ZU;2-#
Abstract
A novel route to functionalized 3-aminopyridazines by reaction of 6-su bstituted 3-chloro-1,2,4-triazines with carbon nucleophiles bearing a cyano substituent at a carbanionic center was developed and a key part of the reaction mechanism was elucidated based on the results of stud ies using N-15-labelled phenylacetonitrile Copyright (C) 1996 Elsevier Science Ltd