PENETRATION OF CEFPODOXIME INTO UTERINE AND VAGINAL SECRETIONS FROM POSTPARTUM WOMEN AFTER A SINGLE ORAL DOSE OF CEFPODOXIME PROXETIL

We evaluated the usefulness of cefpodoxime proxetil (CPDX-PR) in the t reatment of puerperal infection and obtained the following results, (i ) The susceptibilities of 124 clinical isolates from 85 uterine lochia samples were determined, The MIC at which the growth of Streptococcus agalactiae, Escherichia coli, and Bacteroides fragilis isolates was i nhibited by 90% (MIC(90)) was 0.39 mu g/ml or less, The MIG(90) for St aphylococcus aureus was 3.13 mu g/ml, (ii) Seven puerperal women recei ved 200 mg of CPDX-PR orally, The CPDX concentration in the lochias in the uterine cavity was not statistically different from that in the v agina, suggesting that the vaginal samples, which can be obtained more safely and aseptically, can be substituted for the uterine samples, T he CPDX concentration in cubital venous blood reached a peak of 1.61 m u g/ml at 3 hours after CPDX-PR administration, The CPDX concentration in the lochias gradually increased and reached a peak of 1.20 mu g/ml in the uterine cavity and 1.27 mu g/ml in the vagina at 5 h after dru g administration and gradually declined thereafter, These results sugg est that CPDX-PR, with its good transfer to the lochia and its potent antimicrobial activity, is a promising drug for the prophylactic and t herapeutic treatment of puerperal infections caused by susceptible org anisms.