IN-VITRO ACTIVITIES OF AZITHROMYCIN AND DOXYCYCLINE AGAINST 15 ISOLATES OF CHLAMYDIA-PNEUMONIAE

Citation
J. Gnarpe et al., IN-VITRO ACTIVITIES OF AZITHROMYCIN AND DOXYCYCLINE AGAINST 15 ISOLATES OF CHLAMYDIA-PNEUMONIAE, Antimicrobial agents and chemotherapy, 40(8), 1996, pp. 1843-1845
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
ISSN journal
00664804
Volume
40
Issue
8
Year of publication
1996
Pages
1843 - 1845
Database
ISI
SICI code
0066-4804(1996)40:8<1843:IAOAAD>2.0.ZU;2-8
Abstract
Fourteen isolates of Chlamydia pneumoniae, 12 from clinically ill pati ents and 2 from subjectively healthy individuals from an area within a 400-km proximity of Gavle, Sweden, and strain IOL-207, originally fro m the eye of an Iranian child, were tested for susceptibilities to the antibiotics doxycycline and azithromycin, MICs and minimum chlamydiac idal concentrations were found to correlate well with values reported earlier by other investigators, In addition to MIC and minimum chlamyd iacidal concentration testing, testing for the viability of C. pneumon iae after exposure to antibiotic concentrations as high as 50 mg/liter was carried out by passaging antibiotic-treated, infected cell cultur es four times in the absence of antibiotics, It was found that all Chl amydia strains were viable after four passages, regardless of the init ial antibiotic concentration in the cell culture.