J. Gnarpe et al., IN-VITRO ACTIVITIES OF AZITHROMYCIN AND DOXYCYCLINE AGAINST 15 ISOLATES OF CHLAMYDIA-PNEUMONIAE, Antimicrobial agents and chemotherapy, 40(8), 1996, pp. 1843-1845
Fourteen isolates of Chlamydia pneumoniae, 12 from clinically ill pati
ents and 2 from subjectively healthy individuals from an area within a
400-km proximity of Gavle, Sweden, and strain IOL-207, originally fro
m the eye of an Iranian child, were tested for susceptibilities to the
antibiotics doxycycline and azithromycin, MICs and minimum chlamydiac
idal concentrations were found to correlate well with values reported
earlier by other investigators, In addition to MIC and minimum chlamyd
iacidal concentration testing, testing for the viability of C. pneumon
iae after exposure to antibiotic concentrations as high as 50 mg/liter
was carried out by passaging antibiotic-treated, infected cell cultur
es four times in the absence of antibiotics, It was found that all Chl
amydia strains were viable after four passages, regardless of the init
ial antibiotic concentration in the cell culture.