Diseases from the major pathophysiological subgroups, including inflam
matory, infectious, neoplastic, autoimmune, and metabolic disorders, c
an present in a very similar clinical manner, The importance of genera
ting a broad differential diagnosis is supported by a case in which an
80-year-old white man presented with a verrucous plaque on the tip of
his nose, The appropriate differential diagnosis for such a lesion as
well as an overview of the disease diagnosed, North American blastomy
cosis, is presented.