IMMUNOPHARMACOLOGICAL THERAPY IN RENAL-TRANSPLANTATION

Authors
Citation
As. Shoker, IMMUNOPHARMACOLOGICAL THERAPY IN RENAL-TRANSPLANTATION, Pharmacotherapy, 16(4), 1996, pp. 562-575
Citations number
151
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
02770008
Volume
16
Issue
4
Year of publication
1996
Pages
562 - 575
Database
ISI
SICI code
0277-0008(1996)16:4<562:ITIR>2.0.ZU;2-M
Abstract
The long-term kidney allograft survival rate is still far from optimum . Conventional immunosuppressive drugs used to prevent allograft rejec tion are associated with significant side effects. Moreover, withdrawa l of these agents is often associated with graft loss due to rejection . No treatment is available for chronic rejection. Graft tolerance is difficult to achieve in humans, and therefore a continued goal in orga n transplantation is to develop immunosuppressive regimens that are as sociated with fewer side effects and decreased rates of rejection, and that promote graft tolerance. The advent of newer pharmacologic agent s and bioreagents is expected to improve patient and graft survival ra tes.