SERTRALINE-ASSOCIATED SYNDROME OF INAPPROPRIATE ANTIDIURETIC-HORMONE - CASE-REPORT AND REVIEW OF THE LITERATURE

Selective serotonin reuptake inhibitors have gained widespread use in the treatment of depression. A 78-year-old woman became hyponatremic 3 days after being treated with sertraline and was subsequently diagnos ed with the syndrome of inappropriate antidiuretic hormone (SIADH). Sh e became symptomatic, but experienced rapid resolution of the laborato ry and clinical abnormalities associated with SIADH on discontinuing s ertraline and receiving fluid restriction, hypertonic saline, and deme clocycline. Several mechanisms may relate SIADH and vasopressin releas e to serotonin.