Rl. Rodwell et al., GRANULOCYTE-COLONY-STIMULATING FACTOR TREATMENT FOR ALLOIMMUNE NEONATAL NEUTROPENIA, Archives of Disease in Childhood, 75(1), 1996, pp. 57-58
Granulocyte colony stimulating factor (G-CSF) treatment was successful
ly used in three preterm infants with alloimmune neonatal neutropenia
(AINN). Two infants had persistent neutropenia despite treatment with
intravenous immunoglobulin and random donor granulocyte transfusions f
or presumed sepsis. Neutrophil counts returned to normal with G-CSF tr
eatment; the response was least convincing in one infant with fulminan
t necrotising enterocolits. It is suggested that treatment with G-CSF
be considered early for the treatment of infants with AINN.