WIDESPREAD ERUPTIVE DERMAL AND ATYPICAL MELANOCYTIC NEVI IN ASSOCIATION WITH CHRONIC MYELOCYTIC-LEUKEMIA - CASE-REPORT AND REVIEW OF THE LITERATURE

Eruptive nevi have been associated with local skin trauma and immunosu ppression, and atypical eruptive nevi preceding melanoma have been rep orted in immunocompromised transplant patients. We describe a 25-year- old man with widespread eruptive atypical and dermal melanocytic nevi in association with chronic myelocytic leukemia. Our patient's disease differs from earlier reports of eruptive nevi because his nevi appear ed before induction chemotherapy. Eruptive nevi may have been a prodro me to leukemia in this patient. His nevi were histologically similar t o eruptive-atypical nevi observed in AIDS patients and may imply a lin k between systemic immunosuppression and melanocyte proliferation. We suggest that patients in whom eruptive nevi develop in association wit h immunosuppression should be carefully observed for the development o f melanoma skin cancer.