ALTERATIONS IN T-CELLS OF CANCER-BEARERS - WHENCE SPECIFICITY

T cells of tumor-bearing mice and cancer patients have been reported t o have altered signal-transduction machinery. These alterations have b een implicated in immunological suppression. Here, Daniel Levey and Pr amod Srivastava critically examine the evidence for these alterations in the context of the tumor specificity of immunological unresponsiven ess in tumor-bearing hosts.