SYNTHESIS OF NIRURISIDE A HIV REV RRE BINDING INHIBITOR/

Authors
DUYNSTEE HI OVAA H VANDERMAREL GA VANBOOM JH
Citation
Hi. Duynstee et al., SYNTHESIS OF NIRURISIDE A HIV REV RRE BINDING INHIBITOR/, Recueil des travaux chimiques des Pays-Bas, 115(6), 1996, pp. 339
Citations number
6
Categorie Soggetti
Chemistry
Journal title
Recueil des travaux chimiques des Pays-Bas → ACNP
ISSN journal
01650513
Volume
115
Issue
6
Year of publication
1996
Database
ISI
SICI code
0165-0513(1996)115:6<339:SONAHR>2.0.ZU;2-J
Abstract
Regioselective acylation of 2,1':4,6-di-O-isopropylidene-D-sucrose (2) with trans-cinnamoyl chloride gave intermediate 3, which was transfor med in four steps into niruriside (1) in 23% overall yield. On the oth er hand, conversion of 2 into 1',2,4,6-tetra-O-acetylsucrose 10 follow ed by cinnamoylation gave (1) in 41% overall yield.