IN-VIVO PURGING WITH HIGH-DOSE CYTARABINE FOLLOWED BY HIGH-DOSE CHEMORADIOTHERAPY AND REINFUSION OF UNPURGED BONE-MARROW FOR ADULT ACUTE MYELOGENOUS LEUKEMIA IN FIRST COMPLETE REMISSION
As. Stein et al., IN-VIVO PURGING WITH HIGH-DOSE CYTARABINE FOLLOWED BY HIGH-DOSE CHEMORADIOTHERAPY AND REINFUSION OF UNPURGED BONE-MARROW FOR ADULT ACUTE MYELOGENOUS LEUKEMIA IN FIRST COMPLETE REMISSION, Journal of clinical oncology, 14(8), 1996, pp. 2206-2216
Purpose: To evaluate in a prospective study the efficacy of autologous
bone marrow transplantation (BMT) in adult patients with acute myelog
enous leukemia (AML) in first remission, using a single course of high
-dose Cytarabine (HD Ara-C) consolidation therapy as in vivo purging.
Patients and Methods: Sixty consecutive adult patients with AML in fir
st complete remission (CR) were treated with HD Ara-C consolidation th
erapy as a method of in vivo purging before marrow collection. High-do
se therapy consisted of fractionated total-body irradiation (FTBI) 12
Gy, intravenous etoposide 60 mg/kg, and cyclophosphamide 75 mg/kg, fol
lowed by reinfusion of cryopreserved marrow. Results: Sixty patients u
nderwent consolidation treatment with HD Ara-C with the intent to trea
t with autologous BMT. Sixteen patients were unable to proceed to auto
logous BMT (10 patients relapsed, one died of sepsis, one developed ce
rebellar toxicity, two had inadequate blood counts, and two refused).
forty-four patients underwent autologous BMT and have a median follow-
up time of 37 months (range, 14.7 to 68.7) for patients who are alive
with no relapse. The cumulative probability of disease-free survival (
DFS) at 24 months in the intent-to-treat group is 49% (95% confidence
interval [CI], 37% to 62%) and in those who actually underwent autolog
ous BMT is 61% (95% CI, 46% to 74%). The probability of relapse was 44
% (95% CI, 31%, to 58%) and 33% (95% CI, 20% to 49%) for the intent-to
-treat and autologous BMT patients, respectively. Conclusion: This app
roach offers a relatively high DFS rate to adult patients with AML in
first CR. The results of this study are similar to those achieved with
allogeneic BMT. (C) 1996 by American Society of Clinical Oncology.