OBJECTIVE AND IMPORTANCE: Intracerebral schwannomas not associated wit
h cranial nerves account for less than 1% of surgically treated schwan
nomas of the central and peripheral nervous system. Subfrontal schwann
omas are extremely rare, with only 15 cases reported to date. CLINICAL
PRESENTATION: A 33-year-old man presented with a 4-month history of p
rogressive headaches and lethargy. Radiographic studies revealed a lar
ge subfrontal tumor thought to be a meningioma preoperatively. INTERVE
NTION: The patient underwent a craniotomy for resection of his tumor.
Intraoperatively, a large extra-axial tumor arising from the floor of
the left frontal fossa was encountered. CONCLUSION: Microscopic examin
ation of the tumor revealed a schwannoma. Several theories on the poss
ible origin of intracerebral schwannomas have been considered. Because
of the age of the patient at presentation, many authors have postulat
ed a developmental origin for these lesions. However, extra-axial schw
annomas not associated with cranial nerves often present later in life
, suggesting a different pathogenesis for this subgroup.