ANTI FREE-RADICAL ACTION OF CALCIUM-ANTAGONISTS AND H-1 AND H-2 RECEPTORS ANTAGONISTS IN NEOPLASTIC DISEASE

The blood of the subjects suffering from Neoplastic Disease (ND) shows phenomena of membrane peroxidation due to the presence of Free Radica ls (FRs), in a quantity much greater than the one observed in the bloo d of healthy subjects. This can be detected either by calculating the time necessary for the formation of ''Heinz bodies'' (Hbs), (p < 0.000 01) after oxidative stress of the blood in vitro with acetylphenylidra zine (APH), or by calculating the methemoglobin (metHb) quantity that forms after the same treatment (P < 0.00001). The statistical analyses we carried out showed that metHb formation was not affected by age, s ex, smoking habits, red blood cell number, Hb, Ht or tumor staging . I n this study, by using equal parameters of investigation, we noted tha t the blood of the subjects with ND who were previously treated with c alcium-antagonists drugs and with antagonists of H-1 and H-2 receptors , gave results completely superimposable on the results obtained from healthy subjects.