NONRANDOM PRIMARY AND SECONDARY CHROMOSOMAL-ABNORMALITIES IN HUMAN GASTRIC CANCERS

By using Giemsa-banding and fluorescence in situ hybridization techniq ues, we have been able to identify primary and secondary cytogenetic a bnormalities in four gastric tumors at different stages of development . Structural and numerical abnormalities were present in all four gast ric tumors in chromosomes 3, 7, 11, and X. Other abnormalities involvi ng chromosomes 1, 5, 6, 8, 13, 15, 17, 18, 19 and 22 were observed, bu t only in three advanced gastric tumors, suggesting that these were se condary/tertiary genetic defects. Based on these results it was possib le for us to decipher primary and secondary genetic abnormalities in t hese four gastric tumors.