GROWTH-SUPPRESSIVE ACTIVITIES OF SERINE-PROTEASE INHIBITORS, ONO-3403AND ONO-5046, TOWARD NORMAL AND TRANSFORMED MURINE FIBROBLASTS

ONO-3403 and ONO-5046 are potent synthetic protease inhibitors of tryp sin and elastase, respectively. These compounds suppressed the prolife ration of polyoma virus- and Kirsten sarcoma virus-transformed BALB/c 3T3 cells more effectively than their normal counterparts. SV40-transf ormed 3Y1 and v-Ha-ras-transformed NIH3T3 cells were also more sensiti ve to ONO-3403 and ONO-5046 than the parent normal cells. These result s suggest that ONO-3403 and ONO-5046 are useful for selective suppress ion of the proliferation of rapidly growing transformed cells.