HUMAN DNA TOPOISOMERASE .2. BIOCHEMISTRY AND ROLE IN CHEMOTHERAPY RESISTANCE (REVIEW)

Authors
WITHOFF S DEJONG S DEVRIES EGE MULDER NH
Citation
S. Withoff et al., HUMAN DNA TOPOISOMERASE .2. BIOCHEMISTRY AND ROLE IN CHEMOTHERAPY RESISTANCE (REVIEW), Anticancer research, 16(4A), 1996, pp. 1867-1880
Citations number
177
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
16
Issue
4A
Year of publication
1996
Pages
1867 - 1880
Database
ISI
SICI code
0250-7005(1996)16:4A<1867:HDT.BA>2.0.ZU;2-S
Abstract
Recently, it has been discovered that DNA topoisomerases are the targe t of many anti-cancer drugs which were already widely used in the clin ic. Using the latest molecular biological techniques much has been lea rned about the function of DNA topoisomerases in normal cells and in c ancer cells, and about how anticancer drugs inhibit these enzymes. In this review we present an overview of the function of human type II DN A topoisomerases, how they are inhibited by certain drugs and on how c ancer cells may become resistant to these drugs.