MODIFICATIONS OF INTERPHASIC NORS AS A DIAGNOSTIC PARAMETER OF ATYPICAL LESIONS OF THE FEMALE BREAST

Seventy-five breast samples including normal tissue, hyperplastic, met aplastic, atypical and neoplastic lesions were employed for the determ ination of interphasic Nucleolar Organizer Regions (NORs) modification and Proliferating Cell Nuclear Antigen (PCNA) immunoreactivity. Inter phase NORs wee quantitatively and qualitatively modified in atypical l esions and breast carcinomas, whereas only modifications in the Ag-NOR s count were found in benign samples. Our results investigated the nat ure on interphase NORs in the hope of finding a use for their evaluati on in the diagnosis and biological clarification of breast epithelial atypia.