EVALUATION OF 2 DOSE INDIVIDUALIZATION METHODS FOR CARBOPLATIN

The pharmacokinetics of carboplatin are usually evaluated by measuring plasma concentrations of ultrafiltered platinum (UP). This approach, however may be less reliable than measuring the plasma concentration o f total platinum (TP). In a group of 14 patients, which constituted a reference group, the clearance, as estimated by the method of Cockroft , and Gault. This relationship, together with only morphological and b iological parameters, was used to estimate TP clearance, Vc and AUC, a n a validation group of 8 patients. Estimated TP clearance was 97.9 +/ - 18% of the actual value. The TP pharmacokinetic parameters of the re ference group were used to estimate those of the validation group, usi ng only two or three plasma concentration measurements (Bayesian appro ach). With the Bayesian approach, the estimated TP clearance was up to 99.9 +/- 2.7% of the actual value. In conclusion, estimation of TP ph armacokinetics may be reliably estimated as an alternative to UP in cl inical practice.