The discipline of mass spectrometry is nearly a century old. Like any
experimental scientific endeavor, the machines and the science get irr
etrievably mixed with the development of one stimulating the other in
a symbiotic manner. In this paper the authors select a few of the impo
rtant recent successes to highlight the incredible growth of mass spec
trometry over the past several decades. The topic choices made are per
sonal but hopefully serve as an indicator of the current excitement in
this rapidly evolving field. Selections are made from nuclear physics
, through the broad spectrum of the chemical sciences, to the borders
of biology.