SYSTEMIC LUPUS-ERYTHEMATOSUS DIAGNOSED DURING INTERFERON-ALFA THERAPY

We describe a patient who had clinical manifestations of several autoi mmune disorders: Sjogren's syndrome, benign hypergammaglobulinemic pur pura of Waldenstrom, and systemic lupus erythematosus (SLE). The SLE w as diagnosed during therapy with interferon alfa. Testing for anti-Ro and anti-La antibodies was negative until the serum was diluted to eli minate a possible prozone phenomenon of antibody excess.