THE SYNTHESIS OF BISGUANIDINOALKANES AND GUANIDINOALKANES, N-SUBSTITUTED OR N'-SUBSTITUTED WITH PYRIMIDINES, AS ANALOGS OF CHLORHEXIDINE

A series of N,Ntriple -alkanediylbis[N'-(5-halopyrimidin-2-yl)guanidin e] salts has been synthesized along with N,Ntriple ,4-diyl)bis[N'-(5-c hloropyrimidin-2-yl)guanidine], N,Ntriple 1,4-diyl)bis[N'-(5-chloropyr imidin-2-yl)guanidine] dihydrochloride and -aminocyclohexan-1-yl)-N'-( 5-chloropyrimidin-2-yl) guanidine dihydrochloride. Furthermore, a seri es of N-(alkan-1-yl)-N'-(5-chloropyrimidin-2yl)guanidine hydrochloride s and nohexan-1-yl)-N'-(5-chloropyrimidin-2-yl)guanidine dihydrochlori de were synthesized. This series of compounds was prepared by displace ment reactions of 2-methylsulfonylpyrimidines with bisguanidinoalkanes or by condensation of 5-chloro-2-cyanoaminopyrimidine (5-chloropyrimi din-2-ylcyanamide) with alkylamines.