Adequate prehospital care of the severely traumatised patient is impor
tant to prevent or attenuate early as well as late life threatening co
mplications, such as tissue hypoxia, ischemia/reperfusion injury and f
inally multiple organ failure. A mismatch of oxygen supply and oxygen
demand is a hallmark in the pathophysiology of multiple trauma. Oxygen
supply may be diminished by the following factors: shock-related decr
ease of cardiac output, anemia and hypoxia. On the other hand, oxygen
demand may be increased by pain, panic, and agitation. Hence, it is a
central point in prehospital care to reduce this supply-demand imbalan
ce by identification and prompt reversal of the underlying causes. Mos
t often, shock is caused by hypovolaemia and tissue injury (''traumati
c-hemorrhagic shock''). However, shock may also be a result of central
nervous system injury (neurogenic shock as a special form of distribu
tive shock) or circulatory obstruction, e.g tension pneumothorax or ca
rdiac tamponade (obstructive shock). Volume resuscitation by means of
crystalloid or colloid solutions is an essential part in the therapy o
f the traumatic-haemorrhagic shock. In addition, catecholamines may be
necessary in order to achieve an adaequate arterial pressure. However
, if bleeding cannot be controlled in the prehospital setting, only mo
derate volume support and permissive hypotension as well as rapid tran
sportation into the next hospital may be preferable. This may be the c
ase in penetrating thoracic or abdominal injuries as well as in trauma
tic amputations of the proximal limb. On the contrary in patients with
severe head injury, hypotension must be avoided by all means. Obstruc
tive shock has to be treated urgently by insertion of a chest drain or
drainage of the pericardium, respectively. Under all circumstances, i
t is an essential part of prehospital therapy to provide sufficient an
algesia as soon as possible. Prehospital anesthesia, combined with art
ificial ventilation may be necessary for optimal patient management. F
urthermore, ventilatory support is indicated when respiratory failure,
loss of consciousness, or severe shock are present. Additional oxygen
should be given whenever possible, even in the absence of an overt hy
poxic state. Important additional measures are cervical spine immobili
sation and reposition as well as splinting of long bone fractures or l
uxations, in order to avoid secondary injury of the spinal cord or ong
oing tissue and vascular damage.