NEUTRONS AFFECT ADP-RIBOSYLATION OF PROTEINS IN HUMAN KIDNEY T1-CELLSIN-VITRO

ADP-ribosylation (ADPR) of proteins has been shown to be involved with a variety of cellular responses in which chromatin organization and f unctions are affected. In order to look into this response, human kidn ey Tl-cells were exposed in vitro to various doses up to 3 Gy of 6 MeV neutrons and compared with the effect caused by gamma photons. Wherea s in case of neutrons the maximal inhibition of ADPR was reversed at 0 .37 qt that in case of gamma-rays occurred at 1.5 Gy. For the reversal of inhibition of ADPR of proteins in Tl-cells, neutrons were about 4- fold more efficient as compared to gamma rays.